It is known that finite-time blow-up in the 3D Patlak-Keller-Segel system may occur for arbitrarily small values of the initial mass. It’s interesting whether one can prevent the finite-time blow-up via the stabilizing effect of the moving fluid. Consider the three-dimensional Patlak-Keller-Segel system coupled with the linearized Navier-Stokes equations near the Couette flow in a finite channel with and , with the non-slip boundary condition, and we show that if the shear flow is sufficiently strong (A is large enough), then the solutions to Patlak-Keller-Segel-Navier-Stokes system are global in time as long as the initial cell mass is sufficiently small (for example, ) and , which seems to be the first result of considering the suppression effect of Couette flow in the 3D Patlak-Keller-Segel-Navier-Stokes model, and also the first time considering the non-slip boundary condition.

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