This paper focuses on optimal constants and optimizers of the second order Caffarelli-Kohn-Nirenberg inequalities. Firstly, we aim to study optimal constants and optimizers for the following second order Caffarelli-Kohn-Nirenberg inequality in radial space: let , , \begin{equation}\label{0.1} \left(\int_{^N} \frac{|Δu|^p}{|x|^{pα}} x\right)^{\frac{1}{p}} \left[\int_{^N} \frac{\left|\nabla u\right|^{\frac{p(t-1)}{p-1}}} {|x|^{\frac{p(t-1)}{p-1}β}} x\right]^{\frac{p-1}{p}} \ge C(N,p,t,α,β) \int_{^N} \frac{\left|\nabla u\right|^t}{|x|^{tγ}} x. \end{equation} Secondly, we establish second order -Caffarelli-Kohn-Nirenberg identities, and obtain optimal constants and optimizers of the second order -Caffarelli-Kohn-Nirenberg inequalities (i.e., in \eqref{0.1}) in general space. Lastly, under some more general assumptions, we consider the optimal weighted second order Heisenberg Uncertainty Principles, which complements the recent work [``The sharp second order Caffareli-Kohn-Nirenberg inequality and stability estimates for the sharp second order uncertainty principle’', 2022, arXiv:2102.01425]. This paper’s main novelty lies in the fact that we research the optimal versions of the second order Caffarelli-Kohn-Nirenberg inequalities \eqref{0.1} in radial space or in general space, and also establish the second order -Caffarelli-Kohn-Nirenberg identities.

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