This paper is devoted to the study of Mean-field Games (MFG) systems in the mass critical exponent case. We firstly establish the optimal Gagliardo-Nirenberg type inequality associated with the potential-free MFG system. Then, under some mild assumptions on the potential function, we show that there exists a critical mass such that the MFG system admits a least energy solution if and only if the total mass of population density satisfies . Moreover, the blow-up behavior of energy minimizers are captured as . In particular, given the precise asymptotic expansions of the potential, we establish the refined blow-up behavior of ground states as While studying the existence of least energy solutions, we establish new local estimates of solutions to Hamilton-Jacobi equations with superlinear gradient terms.

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