We propose that generalized symmetries in some string-constructed QFTs are given by K-theory. We thus have and symmetries determined by , the twisted K-theory as D-brane charges on the asymptotic boundary of internal geometry with twist class . For these QFTs, ``" are no longer separately well-defined for individual , but are instead mixed together. We discuss 6D ADE-type (2,0) SCFTs and some 6d (1,0) LSTs as examples and demonstrate their twisted K-theoretic symmetries, and we checked them to be compatible with T-duality. We further point out, through explicit examples, that K-theory leads to symmetry extensions that cannot be detected by cohomology for Type II string theory on certain orbifolds of and . We also discuss the implications of these results in the dual brane descriptions.

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