We consider the semilinear heat equation for a large class of non scale invariant nonlinearities of the form , where is Sobolev subcritical and is a slowly varying function (which includes for instance logarithms and their powers and iterates, as well as some strongly oscillating functions). For any positive radial decreasing blow-up solution, we obtain the sharp, global blow-up profile in the scale of the original variables , which takes the form: This estimate in particular provides the sharp final space profile and the refined space-time profile. As a remarkable fact and completely new observation, our results reveal a {\it structural universality} of the global blow-up profile, being given by the “resolvent” of the ODE, composed with a universal, time-space building block, which is the same as in the pure power case.

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