In this work, we investigate the sequence of monic q-Hermite I-Sobolev type orthogonal polynomials of higher-order, denoted as , which are orthogonal with respect to the following non-standard inner product involving q-differences: \begin{equation*} \langle p,q\rangle_{λ}=\int_{-1}^{1}f\left( x\right) g\left(x\right) (qx,-qx;q){\infty }d{q}(x)+λ,(\mathscr{D}{q}^{j}f)(α)(\mathscr{D}{q}^{j}g)(α), \end{equation*} where , belongs to the set of positive real numbers, denotes the -th -discrete analogue of the derivative operator, and denotes the orthogonality weight with its points of increase in a geometric progression. We proceed to obtain the hypergeometric representation of and explicit expressions for the corresponding ladder operators. From the latter, we obtain a novel kind of three-term recurrence formula with rational coefficients associated with these polynomial family. Moreover, for certain real values of , we present some results concerning the location of the zeros of and we perform a comprehensive analysis of their asymptotic behavior as the parameter varies from zero to infinity.

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