The associated production of Higgs and bosons via vector-boson fusion (VBF) is highly sensitive to the relative sign of the Higgs boson couplings to and bosons. In this Letter, two searches for this process are presented, using 140 fb of proton-proton collision data at = 13 TeV recorded by the ATLAS detector at the LHC. The first search targets scenarios with opposite-sign couplings of the and bosons to the Higgs boson, while the second targets Standard Model-like scenarios with same-sign couplings. Both analyses consider Higgs decays into a pair of -quarks and decays with an electron or muon. The opposite-sign coupling hypothesis is excluded with significance much greater than , and the observed (expected) upper limit set on the cross-section for VBF production is 9.0 (8.7) times the Standard Model value.

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