A search is presented for the pair-production of heavy vector-like quarks in the lepton+jets final state using 140 fb of proton-proton collisions at TeV collected with the ATLAS detector. The search is optimised for vector-like top-quarks () that decay into a boson and a -quark, with one boson decaying leptonically and the other hadronically. Other vector-like quark flavours and decay modes are also considered. Events are selected with one high transverse-momentum electron or muon, large missing transverse momentum, a large-radius jet identified as a boson, and multiple small-radius jets, at least one of which is -tagged. Vector-like -quarks with 100% branching ratio to are excluded at 95% CL for masses below 1700 GeV. These limits are also applied to vector-like -quarks, which decay exclusively into a boson and a -quark. Isospin singlets with are excluded for masses below 1360 GeV.

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