In this paper, we consider the three-dimensional Patlak-Keller-Segel system coupled with the Navier-Stokes equations near the non-parallel shear flow in . We show that if the shear flow is sufficiently strong (A is large enough), then the solutions to Patlak-Keller-Segel-Navier-Stokes system are global in time without any smallness restriction on the initial cell mass as long as the initial velocity satisfies , which seems to be the first result of studying the suppression effect of shear flows for the 3D Patlak-Keller-Segel-Navier-Stokes system. Moreover, it implies that the solutions of the 3D Navier-Stokes equations are global in time if the initial velocity satisfies which also shows the transition threshold for the shear flow in .

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