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The issue of global well-posedness for the 3D inhomogenous incompressible Navier-Stokes equations was first addressed by Kazhikov in 1974. In this manuscript, we obtain its global well-posedness for the system with density-dependent viscosity under the smallness assumption of initial velocity in the critical space with . To the best of our knowledge, this is the first result about the global well-posedness for which one does not assume any smallness condition on the density when the initial density is far away from vacuum.

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