Two Dehn surgeries on a knot are called cosmetic if they yield homeomorphic three-manifolds. We show for a certain family of null-homologous knots in any closed orientable three-manifold, if the knot admits cosmetic surgeries with a pair of positive surgery coefficients, then the coefficients are both greater than . In addition, for this family of knots, we show that Dehn surgery for at least is not homeomorphic to the original three-manifold. The proofs of these results use the mapping cone formula for the Heegaard Floer homology of Dehn surgery in terms of the knot Floer homology of the knot; we provide a new proof of this formula for integer surgeries in structures with nontorsion first Chern class.

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