The purpose of this article is to relate coarse cohomology of metric spaces with a more computable cohomology. We introduce a notion of boundedly supported cohomology and prove that coarse cohomology of many spaces are isomorphic to the boundedly supported cohomology. Boundedly supported cohomology coincides with compactly supported Alexander–Spanier cohomology if the space is proper and contractible. Our work generalizes an earlier result of Roe which says that the coarse cohomology is isomorphic to the compactly supported Alexander-Spanier cohomology if the space is uniformly contractible. As an application of our main theorem, we obtain that coarse cohomology of the complement can be computed in terms of Alexander-Spanier cohomology for many spaces.

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