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This paper presents an efficient coupling of the 3D Stokes flow interacting with an effective perforated periodic heterogeneous anisotropic 2D plate. The effective model was obtained by the asymptotic analysis in earlier works and here an effective numerical algorithm is given. By or bi-cubic spacial interpolation the time-dependent problem was reduced to an algebraic system of ordinary differential equation in time. Different examples were given, demonstrating the influence of the structural plate parameters on the solution.

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