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Xe is a candidate isotope for neutrinoless double beta decay~() search. In addition, the two-neutrino case () allowed by the Standard Model of particle physics has not yet been observed. Utilizing the 10.4% of Xe in the natural xenon in the PandaX-4T detector and its first 94.9-day exposure, we have established the most stringent constraints on and of Xe half-lives, with limits of yr and yr at 90% confidence level, respectively. The () limit surpasses the previously reported best result by a factor of 32 (2.7), highlighting the potential of large monolithic natural xenon detectors.

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