In this work, we introduce and study nonlinear Schrödinger equations (NLS) with anisotropic dispersion, where the standard Laplacian acts on the Euclidean variable , and an Ornstein-Uhlenbeck () operator governs the confined direction . We consider models with two natural variants of -induced confinement: (Model Div) based on the divergence form , and (Model Non-Div) based on the non-divergence form . For both models, we establish the Strichartz estimates and Gaussian-weighted Morawetz estimates. In addition, for (Model Div), we prove a virial-type finite-time blow-up result; for (Model Non-Div), we establish global well-posedness and small data scattering in the 2D quintic and 3D cubic cases. The primary motivation of this work is to capture waveguide-type dispersive behavior in a Euclidean setting. To the best of our knowledge, this is the first rigorous analysis of NLS with operators in both divergence and non-divergence forms.

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