Sequence adaptive field-imperfection estimation (SAFE): retrospective estimation and correction of $B_1^{+}$ and $B_0$ inhomogeneities for enhanced MRF quantification

$B_1^{+}$ and $B_0$ field-inhomogeneities can significantly reduce accuracy and robustness of MRF’s quantitative parameter estimates. Additional $B_1^{+}$ and $B_0$ calibration scans can mitigate this but add scan time and cannot be applied retrospectively to previously collected data. Here, we proposed a calibration-free sequence-adaptive deep-learning framework, to estimate and correct for $B_1^{+}$ and $B_0$ effects of any MRF sequence. We demonstrate its capability on arbitrary MRF sequences at 3T, where no training data were previously obtained. Such approach can be applied to any previously-acquired and future MRF-scans. The flexibility in directly applying this framework to other quantitative sequences is also highlighted.