We discuss results from our global QCD analyses including nuclear data off deuterium from various measurements, as well as off H and He targets from the MARATHON experiment. We simultaneously determine the parton distribution functions of the proton, the higher-twist terms, and the nucleon off-shell correction functions responsible for the modifications of the partonic structure in bound protons and neutrons. In particular, we study the neutron-proton asymmetry of the off-shell correction and its interplay with the treatment of the higher-twist terms. We observe that the data on the He/H cross section ratio are consistent with a single isoscalar off-shell function. We also provide our predictions on the ratio and on the and quark distributions in the proton and in the H and He nuclei.

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