Heavy-ion collisions at near-barrier energies provide a crucial pathway for investigating nucleon correlations and clustering structures. Recent experimental results showed that the valence neutrons in light projectiles obviously enhance the transfer. This finding is extremely puzzled and fascinating, because it violates the ground-state value systematics unexpectedly. In this work, the time-dependent Hartree-Fock approach is utilized to investigate the cluster transfer. By comparing the reactions C + Bi, we discover that above puzzling behavior is because of the strong correlation between isospin diffusion and clustering. Our calculations clearly show that the equilibrium of neutron-to-proton ratio strongly inhibits the clustering. This work opens a prospect for investigating the clustering in open quantum system.

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