For Schrödinger operator , acting in the space , necessary and sufficient conditions for semi-boundedness and discreteness of its spectrum.are obtained without assumption that the potential is bounded below. By reduction of the problem to investigation of existence of regular solutions for Riccati PDE necessary conditions for discreteness of the spectrum of operator are obtained under assumption that it is bounded below. These results are similar to ones obtained by author in \cite{Zel} for the one-dimensional case. Furthermore, sufficient conditions for the semi-boundedness and discreteness of the spectrum of are obtained in terms of a non-increasing rearrangement, mathematical expectation and standard deviation from the latter for positive part of the potential on compact domains that go to infinity, under certain restrictions for its negative part . Choosing in an optimal way the vector field associated with difference between the potential and its mathematical expectation on the balls that go to infinity, we obtain a condition for semi-boundedness and discreteness of the spectrum for in terms of solutions of Neumann problem for nonhomogeneous -Laplace equation. This type of optimization refers to a divergence constrained transportation problem.

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