The mapping class group of a smooth manifold is the group of smooth isotopy classes of orientation preserving diffeomorphisms of . We prove a number of results about the mapping class groups of compact, simply-connected, smooth -manifolds. We prove that is non-finitely generated for X = 2n \mathbb{CP}^2 # 10n \overline{\mathbb{CP}^2}, where is odd. Let denote the group of automorphisms of the intersection lattice of that can be realised by diffeomorphisms. Then is an extension of by , the Torelli group of isotopy classes of diffeomorphisms that act trivially in cohomology. We prove that this extension is split for connected sums of , but is not split for 2\mathbb{CP}^2 # n \overline{\mathbb{CP}^2}, where . We prove that the Nielsen realisation problem fails for certain finite subgroups of M( p \mathbb{CP}^2 # q \overline{\mathbb{CP}^2} ) whenever . Lastly we study the extension , where is the group of isotopy classes of diffeomorphisms of which fix a neighbourhood of a point. When or K3 # (S^2 \times S^2) we prove that is a non-trivial extension of by . Moreover, we completely determine the extension class of .

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