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In this article, we characterize Cohen-Macaulay permutation graphs. In particular, we show that a permutation graph is Cohen-Macaulay if and only if it is well-covered and there exists a unique way of partitioning its vertex set into disjoint maximal cliques, where is the cardinality of a maximal independent set of the graph. We also provide some sufficient conditions for a comparability graph to be a uniquely partially orderable (UPO) graph.

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