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In this paper, we study the nonlinear stability for the 3-D plane Poiseuille flow at high Reynolds number in a finite channel with non-slip boundary condition. We prove that if the initial velocity satisfies for some independent of , then the solution of 3-D Naiver-Stokes equations is global in time and does not transit away from the plane Poiseuille flow. To our knowledge, this is the first nonlinear stability result for the 3-D plane Poiseuille flow and the transition threshold is accordant with the numerical result by Lundbladh et al. \cite{LHR}.

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