Meta-Diastereomers Hierarchical Multiscale Chiral Interactions Between Biomolecules and Nanoscale Enantiomers

We introduce meta-diastereomers, hybrid systems where molecular chirality ($\le 10$,nm) and nanoscale chirality ($>100$,nm) combine to create a new hierarchical chiral state with emergent optical properties. By coupling chiral biomolecules electrostatically with enantiomeric silicon nanostructures, we demonstrate how distinct chiral systems can interact to produce optical responses – linear and circular dichroism – that reflect the combined chirality of both components. This unique interplay of chirality across scales represents a conceptual advance in chiral nanophotonics. Importantly, we leverage the meta-diastereomers to probe a model antibody-antigen interaction, analogous to how molecular diastereomers are used in chemistry to investigate chiral structures. This work establishes a platform for label-free, highly specific detection of biomolecular interactions and opens new avenues for exploring hierarchical chirality in optics, biosensing, and quantum technologies.