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In this paper we consider nonlinear elliptic PDEs of the type where and is the critical Sobolev exponent, and allowing the asymptotic behavior of the weight function to be sensitive to the direction. We provide a unified variational approach to obtain existence of distinct solutions in either the unbounded case or when is a smooth bounded domain. A key point is a precise description of the compactness properties of certain sequences of approximating solutions (Palais-Smale sequences), for which we use novel observations on nonexistence in certain regimes. Most of our main results are new in the case of the classical Laplace operator, .

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