Galaxy clusters could produce gamma-rays from inverse Compton scattering of cosmic ray electrons or hadronic interactions of cosmic ray protons with the intracluster medium. It is still an open question on whether gamma-ray emission ( GeV energies) has been detected from galaxy clusters. We carry out a systematic search for gamma-ray mission based on 300 galaxy clusters selected from the 2500 deg. SPT-SZ survey after sorting them in descending order of , using about 15 years of Fermi-LAT data in the energy range between 1-300 GeV. We were able to detect gamma-ray emission with significance of about from one cluster, viz SPT-CL J2012-5649. The estimated photon energy flux from this cluster is approximately equal to MeV cm s. The gamma-ray signal is observed between GeV with the best-fit spectral index equal to . However, since there are six radio galaxies spatially coincident with SPT-CL J2012-5649 within the Fermi-LAT PSF, we cannot rule out the possibility this signal could be caused by some of these radio galaxies. Six other SPT-SZ clusters show evidence for gamma-ray emission with significance between . None of the remaining clusters show statistically significant evidence for gamma-ray emission.

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