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We perform a Lie symmetry analysis on the tempered-fractional Keller Segel (TFKS) system, a chemo-taxis model incorporating anomalous diffusion. A novel approach is used to handle the nonlocal nature of tempered fractional operators. By deriving the full set of Lie point symmetries and identifying the optimal one-dimensional subalgebras, we reduce the TFKS PDEs to ordinary differential equations (ODEs), yielding new exact solutions. These results offer insights into the long-term behavior and aggregation dynamics of the TFKS model and present a methodology applicable to other tempered fractional differential equations.

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