Next-generation neutrinoless double-beta () decay experiments, with projected half-life sensitivities approaching years, aim to probe the entire parameter space of the inverted neutrino mass ordering in the light-neutrino-exchange scenario. However, this reach remains uncertain by the substantial model dependence of the nuclear matrix elements (NMEs). In this work, we propose a strategy based on a combined analysis of decays to both the ground state and the first excited state of the daughter nucleus. We show that such a multi-channel approach can significantly enhance experimental sensitivity, depending on the underlying NME predictions. This method is particularly well-suited for large liquid xenon detectors, such as the proposed PandaX-xT and XLZD experiments, which can efficiently identify transitions of Xe to excited states. Our results highlight the importance of exploiting multiple decay channels in future searches to maximize their discovery potential.

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