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This article primarily aims at introducing a novel operational calculus of Mikusiński’s type for the Dzherbashian-Nersesian operator. Using this calculus, we are able to derive exact solutions for the forward and backward source problems (BSPs) of a differential equation that features Dzherbashian-Nersesian operator in time and intertwined with nonlocal boundary conditions. The initial condition is expressed in terms of Riemann-Liouville integral (RLI). Solution is presented using Mittag-Leffler type functions (MLTFs). The outcomes related to the existence and uniqueness subject to certain conditions of regularity on the input data are established.

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