We propose an alternative method to extract the leading-order hadronic contribution to the muon g-2, , with the MUonE experiment. In contrast to the traditional method based on the integral of the hadronic contribution to the running of the effective fine-structure constant in the space-like region, our approach relies on the computation of the derivatives of at zero squared momentum transfer . We show that this approach allows to extract of the total value of from the MUonE data, while the remaining can be computed combining perturbative QCD and data on annihilation to hadrons. This leads to a competitive evaluation of which is robust against the parameterization used to model in the MUonE kinematic region, thanks to the analyticity properties of , which can be expanded as a polynomial at .

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