We prove sharp characterizations of higher order fractional powers , where is noninteger, ofgenerators of uniformly bounded -semigroups on Banach spaces via extension problems, which in particular include results of Caffarelli-Silvestre, Stinga-Torrea and Galé-Miana-Stinga when . More precisely, we prove existence and uniqueness of solutions , , to initial value problems for both higher order and second order extension problems and characterizations of , , in terms of boundary derivatives of at , under the sharp hypothesis that is in the domain of . Our results resolve the question of setting up the correct initial conditions that guarantee well-posedness of both extension problems. Furthermore, we discover new explicit subordination formulas for the solution in terms of the semigroup generated by .

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