We present new cosmological parameter constraints from the eBOSS Lyman- forest survey. We use a new theoretical model and likelihood based on the PRIYA simulation suite. PRIYA is the first suite to resolve the Lyman- forest in a (~Mpc/h~) volume, using a multi-fidelity emulation technique. We use PRIYA to predict Lyman- forest observables with interpolation error over an dimensional ( simulated, in post-processing) parameter space. We identify an internal tension within the flux power spectrum data. Once the discrepant data is removed, we find the primeval scalar spectral index measured at a pivot scale of Mpc to be at 68% confidence. This measurement from the Lyman- forest flux power spectrum alone is in reasonable agreement with Planck, and in tension with earlier eBOSS analyses. The amplitude of matter fluctuations is at 68% confidence, in agreement with Dark Energy Survey weak lensing measurements and other small-scale structure probes and in tension with CMB measurements from Planck and ACT. The effective optical depth to Lyman- photons from our pipeline is in good agreement with earlier high resolution measurements. We find a linear power at and s/km of with a slope . Our flux power spectrum only chains prefer a low level of heating during helium reionization. When we add IGM temperature data we find and . Our chains prefer an early and long helium reionization event, as suggested by measurements from the helium Lyman- forest. In the near future we will use our pipeline to infer cosmological parameters from the DESI Lyman- data.

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