This paper is devoted to radial solutions of the following weighted fourth-order equation \begin{equation*} (|x|^α\nabla((|x|^α\nabla u)))=u^{2^{}α-1},\quad u>0\quad \mbox{in}\quad ^N, \end{equation*} where , and . It is obvious that the solutions of above equation are invariant under the scaling while they are not invariant under translation when . We characterize all the solutions to the related linearized problem about radial solutions, and obtain the conclusion of that if satisfies for all the radial solution is non-degenerate, otherwise there exist new solutions to the linearized problem that ``replace’’ the ones due to the translations invariance. As applications, firstly we investigate the remainder terms of some inequalities related to above equation. Then when and , we establish a new type second-order Caffarelli-Kohn-Nirenberg inequality \begin{equation*} \int{^N} |(|x|^α\nabla u)|^2 x \geq C \left(\int_{^N}|u|^{2^{}_α} x\right)^{\frac{2}{2^{**}_α}},\quad \mbox{for all}\quad u\in C^\infty_0(^N), \end{equation*} and in this case we consider a prescribed perturbation problem by using Lyapunov-Schmidt reduction.

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