Total positivity of matrices is deeply studied and plays an important role in various branches of mathematics. The main purpose of this paper is to study total positivity of a matrix generated by the weighted lattice paths in from the origin to the point consisting of types of steps: and for , where each step from height~ gets the weight~ and each step from height~ gets the weight . Using an algebraic method, we prove that the -total positivity of the weight matrix implies that of . Furthermore, using the Lindström-Gessel-Viennot lemma, we obtain that both and the Toeplitz matrix of each row sequence of with are -totally positive under the following three cases respectively: (1) , (2) and restrictions for , (3) general and both and are independent of . In addition, for the case (3), we show that the matrix is a Riordan array, present its explicit formula and prove total positivity of the Toeplitz matrix of the each column of . In particular, from the results for Toeplitz-total positivity, we also obtain the Pólya frequency and log-concavity of the corresponding sequence. Finally, as applications, we in a unified manner establish total positivity and the Toeplitz-total positivity for many well-known combinatorial triangles, including the Pascal triangle, the Pascal square, the Delannoy triangle, the Delannoy square, the signless Stirling triangle of the first kind, the Legendre-Stirling triangle of the first kind, the Jacobi-Stirling triangle of the first kind, the Brenti’s recursive matrix, and so on.

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