A search for new heavy scalars with flavour-violating decays in final states with multiple leptons and -tagged jets is presented. The results are interpreted in terms of a general two-Higgs-doublet model involving an additional scalar with couplings to the top-quark and the three up-type quarks (, , and ). The targeted signals lead to final states with either a same-sign top-quark pair, three top-quarks, or four top-quarks. The search is based on a data sample of proton-proton collisions at TeV recorded with the ATLAS detector during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 139f b. Events are categorised depending on the multiplicity of light charged leptons (electrons or muons), total lepton charge, and a deep-neural-network-based categorisation to enhance the purity of each of the signals. Masses of an additional scalar boson between GeV with couplings , , and are excluded at 95% confidence level. Additional interpretations are provided in models of -parity violating supersymmetry, motivated by the recent flavour and anomalies.

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