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We present a new perspective on the study of the behavior of the strong coupling – the fundamental coupling underlying the interactions between quarks and gluons as described by the Quantum Chromodynamics (QCD) – in the low-energy infrared (IR) regime. We rely on the NNSF determination of neutrino-nucleus structure functions valid for all values of from the photoproduction to the high-energy region to define an effective charge following the the Gross-Llewellyn Smith (GLS) sum rule. As a validation, our predictions for the low-energy QCD effective charge are compared to experimental measurements provided by JLab.

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