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We report optical trapping of laser-cooled molecules at sufficient density to observe molecule-molecule collisions for the first time in a bulk gas. SrF molecules from a red-detuned magneto-optical trap (MOT) are compressed and cooled in a blue-detuned MOT. Roughly 30% of these molecules are loaded into an optical dipole trap with peak number density and temperature K. We observe two-body loss with rate coefficient . Achieving this density and temperature opens a path to evaporative cooling towards quantum degeneracy of laser-cooled molecules.

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