The goal of this paper is to provide sharp spectral gap estimates for problems involving higher-order operators (including both the clamped and buckling plate problems) on Cartan-Hadamard manifolds. The proofs are symmetrization-free – thus no sharp isoperimetric inequality is needed – based on two general, yet elementary functional inequalities. The spectral gap estimate for clamped plates solves a sharp asymptotic problem from Cheng and Yang [Proc. Amer. Math. Soc., 2011] concerning the behavior of higher-order eigenvalues on hyperbolic spaces, and answers a question raised in Kristály [Adv. Math., 2020] on the validity of such sharp estimates in high-dimensional Cartan-Hadamard manifolds. As a byproduct of the general functional inequalities, various Rellich inequalities are established in the same geometric setting.

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