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We consider the dynamics of a 2D Bose gas with an interaction potential of the form for . The interaction may be chosen to be negative and large, leading to the instability regime where the corresponding focusing cubic nonlinear Schr{ö}dinger equation (NLS) may blow up in finite time. We show that to leading order, the -body quantum dynamics can be effectively described by the NLS prior to the blow-up time. Moreover, we prove the validity of the Bogoliubov approximation, where the excitations from the condensate are captured in a norm approximation of the many-body dynamics.

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