The Fermi-LAT observations of SN 2023ixf, a Type II supernova in the nearby Pinwheel Galaxy, Messier 101 (M101), presents us with an excellent opportunity to constrain MeV-scale Axion-Like Particles (ALPs). By examining the photon decay signature from heavy ALPs that could be produced in the explosion, the existing constraints on the ALP-photon coupling can be improved, under optimistic assumptions, by up to a factor of for masses MeV. Under very conservative assumptions, we find a bound that is slightly weaker than the existing ones for MeV. The exact reach of these searches depends mostly on properties of the SN progenitor. This study demonstrates the relevance of core-collapse supernovae, also beyond the Magellanic Clouds, as probes of fundamental physics.

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