Let with be the standard higher order derivative Sobolev space in the critical exponential growth threshold. We investigate a new Adams-Adimurthi-Druet type inequality on the whole space which is strongly influenced by the vanishing phenomenon. Specifically, we prove \begin{equation}\nonumber \sup_{\underset{|\nabla^{m} u|{\frac{n}{m}}^{^{\frac{n}{m}}}+|u|{\frac{n}{m}}^{\frac{n}{m}} \leq 1}{u\in W^{m,\frac{n}{m}}(^n)}} \int_{^n}Φ\left(β\left(\frac{1+α|u|{\frac{n}{m}}^{\frac{n}{m}}}{1-γα|u|{\frac{n}{m}}^{\frac{n}{m}}}\right)^{\frac{m}{n-m}}|u|^{\frac{n}{n-m}}\right) x<+\infty. \end{equation} where , for , is the -th order gradient for , , with being the Adams critical constant, and with . In addition, we prove that the constant is sharp. In the subcritical case , the existence and non-existence of extremal function are investigated for and attainability is proven for and in the critical case . Our method to analyze the extremal problem is based on blow-up analysis, a truncation argument recently introduced by DelaTorre-Mancini \cite{DelaTorre} and some ideas by Chen-Lu-Zhu \cite{luluzhu20}, who studied the critical Adams inequality in .

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