The Cherenkov Telescope Array Observatory (CTAO) will be a ground-based Cherenkov telescope performing wide-sky surveys, ideal for anisotropy studies such as cross-correlations with tracers of the cosmic large-scale structure. Cross-correlations can shed light on high-energy -ray sources and potentially reveal exotic signals from particle dark matter. In this work, we investigate CTAO sensitivity to cross-correlation signals between -ray emission and galaxy distributions. We find that by using dense, low-redshift catalogs like 2MASS, and for integration times around 50 hours, this technique achieves sensitivities to both annihilating and decaying dark matter signals that are competitive with those from dwarf galaxy and cluster analyses.

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