We present the Fast Newton Transform (FNT), an algorithm for performing -variate Newton interpolation in downward closed polynomial spaces with time complexity . Here, is a downward closed set of cardinality equal to the dimension of the associated downward closed polynomial space , where denotes the mean of the maximum polynomial degrees across the spatial dimensions . For functions being analytic in an open Bernstein poly-ellipse, geometric approximation rates apply, when interpolating with respect to -sets , in non-tensorial Leja ordered Chebyshev-Lobatto or Leja grids. Especially, the -Euclidean case turns out to be the pivotal choice to mitigate the curse of dimensionality, leading to a ratio that decays exponentially with spatial dimension , while reaching close to or the same approximation power as the tensorial -case. Expanding non-periodic functions, the FNT complements the approximation capabilities of the Fast Fourier Transform (FFT), whereas the choice of -sets renders the FNT time complexity to be less than the FFT time complexity in a wide range of , that exponentially increases with . Maintaining this advantage true for the differentials, the FNT sets a new standard in -variate interpolation and approximation practice.

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