We present new constraints on neutrino secret interactions (SI) by studying high-energy neutrinos from well-known astrophysical sources, such as SN1987A, the blazars TXS and PKS , the active galaxy NGC 1068, and the KM3-230213A neutrino event. We expand existing limits by probing a previously unconstrained region of the mediator mass parameter space. Our study focuses on Dirac neutrinos interacting with a massive spin-one boson as they propagate through the Cosmic Neutrino Background, while also examining Majorana and Dirac neutrinos scattering via a scalar mediator. We consider both ultra-relativistic and non-relativistic regimes, establishing bounds on the SI coupling constant across the wide SI mediator mass range. Our results, obtained using analytical methods, demonstrate significant constraints on the SI vector coupling in the low mediator mass region, compared to the scalar coupling scenario.

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