Miyanishi conjecture claims that for any variety over an algebraically closed field of characteristic zero, any endomorphism of such a variety which is injective outside a closed subset of codimension at least is bijective. We prove Miyanishi conjecture for any quasi-projective variety which is a dense open subset of a -factorial normal projective variety such that codim with the ample canonical divisor or the ample anti-canonical divisor. Also, we observe Miyanishi conjecture without the conditions of its canonical divisor by using minimal model program. In particular, we prove Miyanishi conjecture in the case that has canonical singularities and has the canonical model which is obtained by divisorial contractions.

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