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In this paper, we investigate the global well-posedness and scattering theory for the defocusing energy supcritical inhomogeneous nonlinear Schrödinger equation in four space dimension, where and . We prove that if the solution has a prior bound in the critical Sobolev space, that is, , then is global and scatters. The proof of the main results is based on the concentration-compactness/rigidity framework developed by Kenig and Merle [Invent. Math. 166 (2006)], together with a long-time Strichartz estimate, a spatially localized Morawetz estimate, and a frequency-localized Morawetz estimate.

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