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It is well known that the global well-posedness of the Navier-Stokes equations with temperature-dependent coefficients is a challenging problem, especially in multi-dimensional space. In this paper, we study the 3D Navier-Stokes equations with temperature-dependent coefficients in the whole space. When the initial density and the initial temperature are linearly equivalent to some large constant states, we establish the first result on the global existence of large strong solution. Moreover, the optimal decay rates of the solution to its associated equilibrium are established when the initial data belong to for some .

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