We show that the direction of renormalization in effective field theory is constrained by fundamental principles in the infraredunitarity, analyticity, and Lorentz invariance. Our theorem, in the spirit of the -theorem in conformal field theory, determines the sign of the one-loop running of couplings in the forward limit, when one inserts two operators whose mass dimensions are identical and even. The theorem holds for a broad class of effective field theories with arbitrary ultraviolet completions. The constraint directly applies to linear positivity bounds derived using tree-level amplitudes in the IR, providing a criterion for whether renormalization effects can preserve the positivity bounds, or lead to their apparent violation. We discuss the phenomenological implications of our theorem in chiral perturbation theory and the Standard Model Effective Field Theory, where our theorem is particularly constraining for the running at dimension eight. We provide several examples and show various extensions and applications even at dimension six.

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