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We present a quantum algorithm for estimating the matrix determinant based on quantum spectral sampling. The algorithm estimates the logarithm of the determinant of an positive sparse matrix to an accuracy in time , exponentially faster than previously existing classical or quantum algorithms that scale linearly in . The quantum spectral sampling algorithm generalizes to estimating any quantity , where are the matrix eigenvalues. For example, the algorithm allows the efficient estimation of the partition function of a Hamiltonian system with energy eigenvalues , and of the entropy of a density matrix with eigenvalues .

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