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We develop a general formalism to describe the Renormalization Group Flow of Schur indices and fusion algebras of BPS line defects in four-dimensional Supersymmetric Quantum Field Theories. The formalism includes and extends known results about the Seiberg-Witten description of these structures. Another application of the formalism is to describe the spectrum of BPS partices of gauge theories with matter in terms of the spectrum of pure gauge theories. Applications to the theory of quantum groups and to the quantization of cluster varieties are also discussed.

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