We present the first search for evidence of neutrino self-interaction with two new, state-of-the-art likelihoods for eBOSS Lyman- data. These are an effective field theory (EFT) likelihood with priors from the Sherwood simulation suite, and a compressed likelihood derived from an emulator built using the PRIYA simulation suite. Previous analyses that combined Planck measurements with eBOSS Lyman- likelihoods based on earlier simulations found a preference for neutrino self-interactions. In contrast, using either of the new eBOSS Lyman- likelihoods, we find that a joint analysis with the cosmic microwave background (CMB) data from Planck prefers a negligible level of neutrino self-interaction, and derive new constraints on the neutrino self-coupling: for Planck + EFT Lyman-, and for Planck + PRIYA Lyman-, at 68% confidence. We also consider Planck in combination with DESI BAO data, and find that the latter does not provide significant constraining power for neutrino self-interactions.

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